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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: Cell Host Microbe. 2015 Mar 26;17(4):466–477. doi: 10.1016/j.chom.2015.02.010

Figure 1. RNase L deficiency in mice enhances the lethality of IAV while decreasing the induction of IL-1β.

Figure 1

(A) Survival of wt and Rnasel−/− mice infected i.n. with IAV. (B) Mean body weights corresponding to panel (A). (C,D) IL-1β and (E,F) TNF-α levels determined by ELISAs at 2 days post-infection (dpi) with IAV in (C,E) lung homogenates and (D,F) BALF. (G) Viral titers from lungs harvested at 7 dpi, determined by plaque assays. horizontal lines, mean ± standard deviation (SD). Significance was determined by (A,B) Kaplan-Meier analysis or (C–G) two-tailed Student’s t tests. *** p<0.001; **p< 0.01; *p<0.05; ns, not significant. Numbers of mice used: (A,B) n= 14; (C,E) n=8; (D) n=11; (F) n=9; and (G) n=8. See also Figure S1.