Table 2.
Mean and 2SD values obtained for 16 organic acids quantitated by GC–MS in four age groups of healthy north Indian pediatric population, concentration of organic acids is given in mmol/mol of creatinine
| Analyte | 1–45 days | 45 days to 1 year | 1–3 years | 3–6 years | 6–12 years | 12–16 years |
|---|---|---|---|---|---|---|
| n = 10 | n = 6 | n = 9 | n = 15 | n = 48 | n = 12 | |
| Mean ± 2SD (range) | Mean ± 2SD (range) | Mean ± 2SD (range) | Mean ± 2SD (range) | Mean ± 2SD (range) | Mean ± 2SD (range) | |
| Lactate | 34.9 ± 22.8 (12.1–57.7) | 21.8 ± 13.4 (8.4–35.2) | 22.5 ± 18 (4.5–40.5) | 9.8 ± 3.2 (3.6–13.0) | 14.8 ± 19.4 (0.0–34.2) | 6.9 ± 7.8 (0.0–14.7) |
| Oxalic acid | 96.3 ± 85.8 (10.5–182.1) | 160.7 ± 10.8 (149.9–171.5) | 85.0 ± 87.4 (0.0–172.4) | 38.4 ± 55.6 (0.0–94.0) | 149.8 ± 180.8 (0.0–330.6) | 69.5 ± 123.2 (0.0–192.2) |
| Pyruvate | 23.1 ± 18.8 (4.3–41.9) | 12.3 ± 1.4 (10.9–13.7) | 20.1 ± 25.0 (0.0–45.1) | 12.9 ± 12.4 (0.5–25.3) | 27.9 ± 40.4 (0.0–68.3) | 17.2 ± 23.6 (0.0–40.8) |
| Methylmalonic acid | 23.7 ± 13.2 (10.5–36.9) | 38.0 ± 27.2 (10.8–65.2) | 29.1 ± 27.8 (1.3–56.9) | 42.5 ± 67.0 (0.0–109.5) | 21.4 ± 13.2 (8.2–34.6) | 21.2 ± 28.4 (0.0–49.6) |
| Ethylmalonic acid | 31.8 ± 23.2 (8.6–55.0) | 24.9 ± 17.4 (7.5–42.3) | 48.1 ± 30.4 (17.7–78.5) | 18.5 ± 21.0 (0.0–39.5) | 27.9 ± 35.0 (0.0–62.9) | 8.6 ± 11.6 (0.0–20.2) |
| Fumaric acid | 19.2 ± 16.8 (2.4–36.0) | 23.3 ± 17.4 (5.9–40.7) | 11.4 ± 8.8 (2.6–20.2) | 10.0 ± 10.6 (0.0–20.6) | 12.7 ± 19.0 (0.0–31.7) | 5.6 ± 6.4 (0.0–12.0) |
| Lactic acid dimer | 15.6 ± 6.4 (9.2–22.0) | 19.4 ± 10.6 (8.4–30.0) | 16.2 ± 7.6 (8.6–23.8) | 15.4 ± 18.2 (0.0–33.6) | 13.1 ± 16.0 (0.0–29.1) | 7.6 ± 9.4 (0.0–17.0) |
| Glutaric acid | 21.2 ± 8.6 (12.6–29.8) | 14.4 ± 20.4 (0.0–34.8) | 15.7 ± 13.8 (1.9–29.5) | 5.3 ± 7.4 (0.0–12.7) | 11.3 ± 15.8 (0.0–27.1) | 6.1 ± 8.8 (0.0–14.9) |
| 3-Methylglutaric acid | 18.5 ± 9.0 (9.5–27.5) | 35.8 ± 22.2 (13.6–58.0) | 26.1 ± 18.8 (7.3–44.9) | 23.7 ± 28.8 (0.0–52.5) | 19.2 ± 21.6 (0.0–30.6) | 10.9 ± 13.6 (0.0–24.5) |
| 3-Phenylbutyric acid | 19.9 ± 7.0 (12.9–26.7) | 37.4 ± 19.8 (17.6–57.2) | 21.8 ± 15.6 (6.2–37.4) | 19.0 ± 21.6 (0.0–40.6) | 21.5 ± 26.8 (0.0–48.3) | 10.2 ± 12.8 (0.0–23.0) |
| Succinylacetone | 12.9 ± 6.0 (6.9–18.9) | 10.6 ± 4.0 (6.6–14.6) | 10.8 ± 4.2 (6.6–15.0) | 12.7 ± 4.8 (7.9–17.5) | 14.9 ± 13.2 (1.7–28.1) | 11.8 ± 15.0 (0.0–26.8) |
| Adipic acid | 20.4 ± 29.4 (0.0–49.8) | 29.0 ± 26.8 (2.2–55.8) | 19.2 ± 21.2 (0.0–40.4) | 11.6 ± 16.6 (0.0–28.2) | 28.1 ± 43.4 (0.0–71.5) | 11.6 ± 17.4 (0.0–29.0) |
| Suberic acid | 19.5 ± 15.6 (3.9–35.1) | 12.9 ± 4.6 (8.3–17.5) | 12.6 ± 19.8 (0.0–32.4) | 10.6 ± 16.0 (0.0–26.6) | 24 ± 37.2 (0.0–61.2) | 15.4 ± 27.0 (0.0–42.4) |
| Azelaic acid | 5.1 ± 4.6 (0.5–9.7) | 19.9 ± 20.0 (0.0–39.9) | 18.0 ± 12.4 (5.6–30.4) | 4.9 ± 10.8 (0.0–15.7) | 18 ± 27.6 (0.0–45.6) | 7.5 ± 13.6 (0.0–21.1) |
| Sebacic acid | 12.9 ± 13.4 (0.0–26.3) | 21.4 ± 13.6 (7.8–35.0) | 8.0 ± 2.9 (2.2–13.8) | 4.6 ± 3.4 (1.2–8.0) | 10.7 ± 16.2 (0.0–26.9) | 4.5 ± 4.8 (0.0–9.3) |
| Orotic acid | 2.1 ± 1.2 (0.9–3.3) | 2.1 ± 2.0 (0.1–4.1) | 3.2 ± 4.2 (0.0–7.4) | 1.3 ± 1.4 (0.0–2.7) | 3 ± 4.8 (0.0–7.8) | 2.0 ± 5.8 (0.0–7.8) |