TABLE 5.
Summary of transcriptome comparison of S. pneumoniae D39 ΔnanR and wild-type D39 grown in SM17 (0.5% sialic acid plus M17)
| D39 locus tag | Functiona | Ratiob |
|---|---|---|
| spd_1487 | Phosphosugar-binding transcriptional regulator, NanR | −1.4 |
| spd_1488 | ROK family protein, NanK | −8.0 |
| spd_1489 | N-Acetylneuraminate lyase, NanA2 | −6.1 |
| spd_1490 | Hypothetical protein | −3.4 |
| spd_1491 | Hypothetical protein | −2.1 |
| spd_1492 | Hypothetical protein | −2.2 |
| spd_1493 | Sugar ABC transporter, permease protein, NanW | −4.1 |
| spd_1494 | Sugar ABC transporter, permease protein, NanV | −5.2 |
| spd_1495 | Sugar ABC transporter, sugar-binding protein, NanU | −4.1 |
| spd_1496 | PTS, IIBC components, NanP | −5.0 |
| spd_1497 | N-Acetylmannosamine-6-phosphate 2-epimerase 2, NanE | −4.6 |
| spd_1504 | Sialidase A, NanA | −5.9 |
a
D39 annotation or TIGR4 annotation (27). PTS, phosphotransferase system.
b
Fold decrease in the expression of genes in the ΔnanR mutant compared to the wild type. nanR is downregulated less than 2-fold but is listed in the table to confirm the deletion of nanR. Errors in the ratio numbers never exceeded 10% of the given values.