Fig. 2.

Reduction in the somatic SV FDR for tumor-specific mutations by simultaneously integrating data from 128 TCGA samples. The somatic FDR is the predicted rate at which somatic SV breakpoints are false, either due to false positive SV calls or due to inherited germline SVs that have been misclassified as somatic due to false negatives. For this experiment, we identify false somatic calls by their presence in a single normal genome but not in the paired tumor genome or any of N additional tumor-normal pairs (X-axis)