Table II. Glucagon stimulation test results of 18 subjects with thalassemia major.
Adrenal Sufficiency | Adrenal Insufficiency | p | |
---|---|---|---|
n | 7 | 11 | n/a |
Age (yrs) | 18.8 ± 7.8 | 19 ± 10.5 | 0.96 |
Female Sex, n (%) | 5 (71) | 2 (18) | 0.049 |
Transfusion history (yrs) | 15.1 ± 7.3 | 17.3 ± 10.6 | 0.6 |
8:00 AM cortisol (mcg/dL) | 9.6 ± 5.3 | 8.0 ± 2.0 | 0.48 |
Peak cortisol (mcg/dL) | 22.1 ± 3.7 | 13.3 ± 2.6 | n/a |
8:00 AM ACTH (pg/mL) | 22 ± 11 | 25 ± 20 | 0.72 |
Peak ACTH (pg/mL) | 97 ± 66 | 47 ± 50 | 0.12 |
Peak GH (ng/mL) | 9.6 (5.5-34) | 7.8 (2.4-32) | 0.47 |
Ferritin (ng/mL) | 2401 ± 1979 | 802 ± 500 | 0.078 |
Days since last transfusion | 14 ± 10 | 13.6 ± 6.8 | 0.93 |
Data are mean ± SD for normally distributed continuous variables; median (10th and 90th percentiles) for non-normally distributed variables; or n (%) for categorical variables