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. 2015 Mar 31;15:203. doi: 10.1186/s12885-015-1209-x

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© Zhao et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MTUS1/ATIP3a knockdown promotes the migration and invasion of SACC. (A) Obviously reductions in ATIP3a protein levels were observed in the ATIP3a siRNA-transfected SACC-83 cells compared to the negative control-siRNA transfected cells. SACC-83 cells displayed increased Slug, Vimentin and pERK1/2 protein levels and decreased E-cadherin protein levels upon ATIP3a knockdown. (B, C) ATIP3a knockdown promotes the migration and invasion of SACC-83 cells. (D) The cell proliferation rate of the SACC-83 cells was significantly promoted after transfection with the ATIP3a siRNA. *: P <0.05.