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. 2015 Mar 18;15:140. doi: 10.1186/s12885-015-1135-y

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© Kachel et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inhibition of FGFR and response in phosphorylation status of PKM2 and LDHA. Inhibiton experiments were performed with Dovitinib and SU-5402, two inhibitors of Fibroblast growth factor receptor (FGFR). Phosphorylation status of PKM2 and LDHA was measured after four hours and showed a significant decrease with Dovitinib 100nM and SU-5402 20 μM for both proteins. DMSO was used as positive control. No significant downregulation of PKM2 and LDHA phosphorylation was detectable with 1nM and 10 nM of Dovitinib.