Table 1.
EGDT protocol and outcome of selected trials
| Study | EGDT group | Control group | Survival benefit |
|---|---|---|---|
| Standard EGDT versus usual care | |||
| ARISE 2014 [13] | ScvO2 ≥ 70% | Usual care | No: 28d/90d/ICU/in-hospital mortality |
| CVP ≥ 8-12 mm Hg | |||
| MAP ≥ 65 mm Hg | |||
| UO ≥ 0.5 ml/kg/h | |||
| Jing 2010 [8] | ScvO2 ≥ 70% | CVP ≥ 8-12 mm Hg | Yes: 28d/ICU mortality |
| CVP ≥ 8-12 mm Hg | SBP > 100 mm Hg | ||
| SBP >100 mm Hg | MAP ≥ 65 mm Hg | ||
| MAP ≥ 65 mm Hg | UO ≥ 0.5 ml/kg/h | ||
| UO ≥ 0.5 ml/kg/h | |||
| ProCESS 2014 [14] | ScvO2 ≥ 70% | Usual care | No: 60d/in-hospital mortality |
| CVP ≥ 8-12 mm Hg | |||
| MAP ≥ 65 mm Hg | |||
| UO ≥ 0.5 ml/kg/h | |||
| Rivers 2001 [4] | ScvO2 ≥ 70% | CVP ≥ 8-12 mm Hg | Yes: 28d/60d/in-hospital mortality |
| CVP ≥ 8-12 mm Hg | MAP ≥ 65 mm Hg | ||
| MAP ≥ 65 mm Hg | UO ≥ 0.5 ml/kg/h | ||
| UO ≥ 0.5 ml/kg/h | |||
| Wang 2006 [25] | ScvO2 ≥ 70% | Usual care | No: 7d/14d mortality |
| CVP ≥ 8-12 mm Hg | |||
| MAP ≥ 65 mm Hg | |||
| UO ≥ 0.5 ml/kg/h | |||
| Modified EGDT versus usual care | |||
| Andrews 2014 [21] | JVP > 3 cm; | Usual care | No: 28d/in-hospital mortality |
| MAP > 65 mm Hg; | |||
| Hb > 7 g/dl | |||
| Lin 2006 [23] | CVP ≥ 8-12 mm Hg; | Usual care | Yes: ICU/in-hospital mortality |
| MAP ≥ 65 mm Hg; | |||
| UO ≥ 0.5 ml/kg/h | |||
| ProCESS 2014 [14] | SBP ≥ 100 mm Hg | Usual care | No: 60d/in-hospital mortality |
| Hb > 7.5 g/dl | |||
| Standard EGDT versus lactate clearance | |||
| Jones 2010 [22] | ScvO2 ≥ 70% | Lactate clearance ≥ 10% | No: in-hospital mortality |
| CVP ≥ 8-12 mm Hg | CVP ≥ 8-12 mm Hg | ||
| MAP ≥ 65 mm Hg | MAP ≥ 65 mm Hg | ||
| UO ≥ 0.5 ml/kg/h | UO ≥ 0.5 ml/kg/h | ||
| Wang 2014 [20] | ScvO2 ≥ 70% | Lactate < 2 mmol/L | No: 7d/28d mortality |
| CVP ≥ 8-12 mm Hg | CVP ≥ 8-12 mm Hg | ||
| MAP ≥ 65 mm Hg | MAP ≥ 65 mm Hg | ||
| UO ≥ 0.5 ml/kg/h | UO ≥ 0.5 ml/kg/h | ||
| Yu 2013 [24] | ScvO2 ≥ 70% | Lactate clearance ≥ 10% | No: 28d mortality |
| CVP ≥ 8-12 mm Hg | CVP ≥ 8-12 mm Hg | ||
| MAP ≥ 65 mm Hg | MAP ≥ 65 mm Hg | ||
| UO ≥ 0.5 ml/kg/h | UO ≥ 0.5 ml/kg/h | ||
Abbreviations: EGDT early goal-directed therapy, SBP systolic blood pressure, JVP jugular venous pressure, MAP mean artery pressure, Hb hemoglobin, UO urine output.