Table 1.
Demographics for HIV-Infected and HIV-Negative Control Subjects
| MALES | P Value† | FEMALES | P Value† | |||
|---|---|---|---|---|---|---|
| HIV+ (N=168) | Controls (N=68) | HIV+ (N=138) | Controls (N=39) | |||
| Demographics | ||||||
|
| ||||||
| Age (Yr) | 43±7 | 41±8 | 0.09 | 41±7 | 41±10 | 0.75 |
|
| ||||||
| Race (%) | 0.17 | 0.81 | ||||
|
| ||||||
| Caucasian | 66.1 | 79.4 | - | 34.8 | 41.0 | - |
|
| ||||||
| African American | 20.2 | 14.7 | - | 46.4 | 41.0 | - |
|
| ||||||
| Hispanic | 9.5 | 2.9 | - | 10.9 | 12.8 | - |
|
| ||||||
| Other | 4.2 | 2.9 | - | 8.0 | 5.1 | - |
|
| ||||||
| BMI (kg/m2) | 26.1±3.9 | 27.1±3.9 | 0.08 | 27.9±5.8 | 27.4±5.1 | 0.60 |
|
| ||||||
| HIV Parameters | ||||||
|
| ||||||
| CD4 (#/mm3) ‡ | 442±250 | 899±383 | <0.0001 | 452±253 | 950±316 | <0.0001 |
|
| ||||||
| Viral Load (copies/mL)¶ ‡ | 50 (50,12150) | - | - | 116 (50,5471) | - | - |
|
| ||||||
| Duration HIV (Yr) ‡ | 8.7±5.0 | - | - | 8.3±4.4 | - | - |
|
| ||||||
| Currently Taking PI (%) | 67.3 | - | - | 44.9 | - | - |
|
| ||||||
| Currently Taking NRTI (%) | 85.7 | - | - | 79.0 | - | - |
|
| ||||||
| Currently Taking NNRTI (%) | 38.0 | - | - | 31.1 | - | - |
|
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| Not Taking Antiretrovirals (%) | 9.5 | - | - | 18.8 | - | - |
|
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| % Categorized with Lipodystrophy | 66.7 | - | - | 73.9 | - | - |
|
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| Metabolic Parameters | ||||||
|
| ||||||
| Total cholesterol (mg/dL)*‡ | 198±50 | 181±37 | 0.01 | 185±44 | 177±34 | 0.29 |
|
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| HDL (mg/dL)*‡ | 38±11 | 45±11 | <0.0001 | 46±13 | 56±15 | <0.0001 |
|
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| Triglyceride (mg/dL)*‡ | 259±231 | 141±147 | 0.0001 | 158±154 | 113±165 | 0.12 |
|
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| Fasting Insulin (μIU/mL)*‡ | 16±15 | 11±8 | 0.04 | 11±8 | 8±6 | 0.047 |
|
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| Insulin AUC (μIU/mL × 120 min)*‡ | 9216±5348 | 6431±4430 | 0.02 | 8683±4953 | 5500±2781 | 0.009 |
|
| ||||||
| Fasting Glucose (mg/dL)*‡ | 93±13 | 90±13 | 0.049 | 86±10 | 86±15 | 0.87 |
|
| ||||||
| Glucose AUC (mg/dL × 120 min)*‡ | 17496±3809 | 15094±3207 | 0.0004 | 15797±3431 | 15925±4515 | 0.89 |
Results expressed as mean ± standard deviation
p values derived from ANOVA test
Results expressed as median (interquartile range)
Data for CD4 available in 19 HIV− males and 128 HIV+/18 HIV− females; for viral load in 48 HIV+ males and 103 HIV+ females; for duration of HIV in 167 HIV+ males; for total cholesterol in 166 HIV+/67 HIV− males and 130 HIV+ females; for triglyceride in 67 HIV− males and 130 HIV+ females; for HDL in 67 HIV− males and 130 HIV+ females; for fasting insulin in 116 HIV+/48 HIV− males and 125 HIV+/37 HIV− females; for insulin AUC in 96 HIV+/25 HIV− males and 110 HIV+/18 HIV− females; for fasting glucose in 67 HIV− males and 130 HIV+ females; for glucose AUC in 147 HIV+/39 HIV− males and 116 HIV+/19 HIV− females
To convert mg/dL to mmol/L for total cholesterol and HDL, multiply by 0.0259; for triglycerides, multiply by 0.0113; for glucose, multiply by 0.0555; and to convert μIU/mL to pmol/L for insulin, multiply by 6.945
Abbreviations: BMI: Body Mass Index, SAT: Abdominal Subcutaneous Adipose Tissue, VAT: Visceral Adipose Tissue, HDL: High-Density Lipoprotein, AUC: Area-Under-the-Curve