Skip to main content

View full-text article in PMC

. 2014 Sep 1;41(3):627–636. doi: 10.1093/schbul/sbu128

Table 3.

Cox Regression and Negative Binomial Regression Analysis Results

	Time to Hospitalization (All Patients)			Time to All-Cause Discontinuation			Time to Hospitalization (Patients Without LAI possession Gap >28 Days)			Number of Bed-Days After Failure for Hospitalization
	N = 4532 (3765 Failures)			N = 4532 (3933 Failures)			N = 4532 (3157 Failures)			N = 3765
	2710.9 patient-years			2892.7 patient-years			1691.1 patient-years			N/A
	HR^a	95% CI	P Value	HR^a	95% CI	P Value	HR^a	95% CI	P Value	IRR^b	95%CI	P Value
Risperidone	0.95	0.87–1.03	.199	0.94	0.86–1.02	.116	1.03	0.93–1.15	.519	0.97	0.78–1.19	.744
Male sex	1.04	0.97–1.11	.274	1.04	0.98–1.12	.208	0.95	0.87–1.05	.302	1.12	0.96–1.30	.163
Year of depot initiation	1.01	1.00–1.02	.126	1.01	1.00–1.02	.055	1.08	1.05–1.11	<.001	0.93	0.91–0.96	<.001
Percentage of time with psychiatric hospitalization during 2 years prior to LAI intiation	1.93	1.75–2.13	<.001	1.88	1.71–2.06	<.001	2.19	1.88–2.55	<.001	7.23	5.81–9.00	<.001
Duration of illness	1.97	1.88–2.06	<.001	1.92	1.84–2.01	<.001	2.17	2.00–2.35	<.001	1.15	1.11–1.19	<.001
Disability pension	1.00	0.93–1.07	.903	1.00	0.94–1.08	.908	1.08	0.97–1.19	.159	1.18	1.00–1.39	.044
Clozapine	1.23	1.09–1.38	.001	1.20	1.07–1.35	.002	1.29	1.10–1.51	.002	2.46	1.90–3.19	<.001
Number of non-psychiatric medications	0.94	0.92–0.95	<.001	0.95	0.93–0.96	<.001	0.93	0.91–0.95	<.001	0.92	0.90–0.94	<.001
Number of psychiatric co-medications	1.07	1.03–1.10	<.001	1.06	1.03–1.10	<.001	1.07	1.03–1.12	<.001	0.83	0.77–0.89	<.001
Inpatient status at time of LAI initiation	0.75	0.64–0.88	<.001	0.77	0.66–0.90	.001	0.75	0.62–0.90	.002	0.85	0.63–1.16	.319

Note: IRR, incidence rate ratio.

^aCox regression analysis.

^bNegative binomial regression analysis, IRR.