Fig. 4.

Frequency distribution of the risk allele of SNP rs17002034 in global populations and protein-protein interaction (PPI) analysis. (A) The risk allele (T) of rs6001974 showed drastic differences in its frequency among global populations. Of note, the A allele (risk allele) is fixed in some populations. (B) MKL1 physically interacts with GSK3B, a protein encoded by a well-known schizophrenia risk gene. Circles represent proteins and edges represent PPIs. MKL1 and GSK3B are marked by red circles. Blue circles represent proteins encoded by schizophrenia susceptibility genes.