Table 1.

Association of 7 SNPs in MKL1 Gene with Schizophrenia

SNP	Chr	Position	A12 c	ORa			P valueb
				PGC + SWEd	Family- Basede	Combinedf	PGC + SWE	Family-Based	Combined
rs10918670	1	167216210	GA	1.054	1.212	1.068	0.013	0.0032	0.0011
rs11584337	1	167248664	TG	1.054	1.213	1.068	0.013	0.0032	0.0011
rs2132303	1	2223258	TC	1.060	0.847	1.031	0.017	0.010	0.181
rs2296268	1	36603165	TC	1.029	1.152	1.048	0.14	0.0013	0.008
rs2636319	1	243501047	CA	0.932	0.882	0.926	4.15×10–5	0.0083	2.03×10–6
rs2636320	1	243501056	CA	0.931	0.882	0.925	3.6×10–5	0.0083	1.57×10–6
rs2643904	1	2236697	GA	0.943	1.341	0.978	0.018	6.54×10–5	0.346
rs3006925	1	243609927	TC	0.905	0.825	0.898	1.42×10–6	0.0045	5.13×10–8
rs3767432	1	167383472	GA	1.060	1.239	1.075	0.0072	0.0017	4.5×10–4
rs3767434	1	167371151	GA	1.060	1.235	1.074	0.0063	0.0024	4.6×10–4
rs4915419	1	200251050	CA	0.943	1.127	0.966	6.3×10–4	0.0064	0.031
rs589249	1	37162352	GA	1.062	1.138	1.073	9.7×10–4	0.0040	3.6×10–5
rs7532692	1	167250080	TC	1.053	1.196	1.067	0.015	0.0048	0.0014
rs10193188	2	152551210	GA	0.953	0.882	0.939	0.034	0.0059	0.0018
rs10445792	2	201078821	CA	1.107	1.179	1.116	8.09×10–6	0.0047	2.19×10–7
rs11687313	2	201146399	GA	0.878	0.783	0.862	8.91 × 10 –8	0.00024	3.58×10 −10
rs11688415	2	201143409	TC	0.876	0.788	0.865	4.98×10–8	3.5×10–4	2.14×10−10
rs11694369	2	200741720	GA	0.885	0.796	0.871	1.29×10–8	6.0×10–4	1.19×10−10
rs13010104	2	208369213	TC	1.117	NA	1.125	7.23×10–7	NA	6.34×10–8
rs13010676	2	208369294	GA	1.116	NA	1.095	8.29×10–7	NA	2.78×10–5
rs1861228	2	103208945	GA	0.971	0.898	0.961	0.091	0.015	0.013
rs4664494	2	152499580	TC	1.040	1.146	1.060	0.089	0.0030	0.0043
rs6713162	2	152496526	GA	1.041	1.121	1.056	0.082	0.040	0.008
rs6739563	2	201134216	TG	1.114	1.189	1.125	1.77 × 10 –6	0.0016	1.95 × 10 −08
rs1010471	3	180691092	GA	1.074	0.875	1.044	5.72×10–5	0.0027	0.0093
rs12496073	3	25033188	GA	1.033	1.154	1.049	0.084	0.0019	0.0057
rs13076055	3	12341996	GA	0.963	1.129	0.986	0.048	0.0083	0.42
rs17203055	3	119084331	GA	1.126	NA	1.085	2.38×10–5	NA	0.0024
rs4684846	3	12338849	GA	1.039	0.885	1.014	0.048	0.0078	0.43
rs6445062	3	172192239	TC	1.061	0.870	1.034	6.1×10–4	0.0015	0.040
rs13120709	4	169435779	TC	1.027	1.121	1.040	0.14	0.012	0.021
rs17001561	4	77096118	GA	1.040	1.207	1.056	0.11	0.0072	0.017
rs29357	4	114209691	GA	1.021	NA	1.002	0.45	NA	0.95
rs566091	4	152852168	GC	0.973	0.855	0.953	0.25	0.0046	0.029
rs1986252	5	60754419	TC	0.931	0.879	0.925	2.1×10–5	0.008	1.06×10–6
rs4604142	5	60642595	TC	1.082	1.138	1.088	2.41×10–6	0.0084	1.21×10–7
rs6898746	5	60843706	TA	0.929	0.869	0.923	1.4×10–5	0.0036	4.48×10–7
rs7734879	5	60711632	CA	0.943	0.883	0.935	7.8×10–4	0.010	4.94×10–5
rs156743	6	27967089	TC	1.163	1.174	1.165	1.47×10–8	0.0079	4.20×10−10
rs16897515	6	27278020	CA	1.157	1.255	1.166	8.20×10−10	0.0026	1.39×10–11
rs2077580	6	32020844	GA	0.962	1.276	0.993	0.23	0.0086	0.82
rs2239523	6	31089507	GC	0.983	0.820	0.965	0.34	4.8×10–4	0.046
rs2857605	6	31524851	GA	1.007	1.185	1.026	0.73	0.0039	0.20
rs3130287	6	32050544	TC	0.949	0.826	0.936	0.024	0.0085	0.0032
rs3130349	6	32147696	GA	NA	1.207	1.207	NA	0.0043	0.0043
rs3132935	6	32171075	GA	NA	0.832	0.832	NA	0.0013	0.0013
rs3132947	6	32176782	TG	NA	0.834	0.834	NA	0.0016	0.0016
rs3134605	6	32159956	GA	NA	0.858	0.858	NA	0.0043	0.0043
rs3134954	6	32071893	GA	1.057	1.217	1.071	0.018	0.0071	0.0021
rs354391	6	66319480	CA	1.030	1.137	1.093	0.13	0.0068	0.015
rs3800316	6	27256102	CA	0.894	0.831	0.888	1.85×10–8	0.0033	4.20×10−10
rs6923836	6	113393530	GA	1.045	0.873	1.021	0.011	0.0022	0.21
rs6940698	6	25821580	TC	0.867	0.700	0.853	3.54×10–6	6.0×10–4	6.06×10–8
rs1229761	7	114223723	TG	1.03	0.827	1.013	0.11	0.0034	0.47
rs13274028	8	8729193	CA	1.041	0.850	1.016	0.025	7.1×10–4	0.352
rs3739396	8	18388041	GA	1.092	1.184	1.104	2.6×10–4	0.0058	1.05×10–5
rs10115971	9	101024887	GA	1.187	0.843	1.136	0.021	0.0026	0.493
rs12343574	9	129440840	CA	1.079	0.825	1.043	0.0081	0.010	0.12
rs1004467	10	104594507	TC	1.157	1.126	1.149	3.00 × 10 –7	0.016	1.77 × 10 –8
rs10883757	10	104400133	TC	0.894	0.892	0.894	2.2×10–4	0.021	1.31×10–5
rs11190913	10	103059038	GA	0.941	1.110	0.959	0.0013	0.051	0.018
rs11191499	10	104764271	TC	1.203	1.158	1.193	5.20×10−10	0.0064	1.32×10–11
rs11191514	10	104773364	TC	0.828	0.865	0.837	2.64×10−10	0.007	8.29×10–12
rs11191548	10	104846178	TC	1.209	1.139	1.193	2.68×10−10	0.02	2.49×10–11
rs11191560	10	104869038	TC	1.209	1.143	1.194	2.05×10−10	0.016	1.70×10–11
rs11594111	10	14945406	GA	0.990	NA	1.007	0.70	NA	0.76
rs11818043	10	104391627	GA	0.888	0.887	0.888	7.77×10–5	0.014	3.47×10−06
rs12221064	10	104677126	TC	0.834	0.866	0.841	9.83×10−10	0.0075	2.93×10–11
rs12413046	10	104871204	GA	0.826	0.879	0.838	1.68×10−10	0.020	1.63×10–11
rs17094683	10	104851301	TC	0.827	0.868	0.836	2.07×10−10	0.0088	8.58×10–12
rs17114803	10	104386934	TC	1.125	1.122	1.124	8.62×10–5	0.018	4.81×10–6
rs2298278	10	104390303	GA	1.126	0.893	1.056	8.09×10–5	0.019	0.034
rs3740387	10	104849468	TC	0.897	0.905	0.898	2.26×10−10	0.018	1.29×10–11
rs3740390	10	104638480	GA	1.195	1.161	1.187	2.21×10–9	0.0054	4.59×10–11
rs4409766	10	104616663	TC	1.159	1.156	1.158	2.26 × 10 –7	0.0035	2.82 × 10 –9
rs4919666	10	104384029	GA	1.126	1.124	1.125	8.71×10–5	0.017	4.45×10–6
rs7897654	10	104662458	TC	1.113	1.121	1.114	6.52×10–9	0.0085	1.72×10−10
rs7923415	10	104418656	TC	0.972	0.879	0.959	0.11	0.0053	0.013
rs1059440	11	63991801	GA	1.052	1.141	1.065	0.025	0.011	0.0022
rs11231727	11	64011854	TC	0.961	0.895	0.952	0.022	0.011	0.002
rs11605738	11	64013406	GA	0.933	0.879	0.924	0.0021	0.013	0.00014
rs3219243	12	109542392	TC	0.961	0.868	0.945	0.062	0.0041	0.0043
rs17065458	13	44704662	TC	1.073	1.177	1.091	0.010	0.0047	4.1×10–4
rs2036130	13	82606614	TC	0.952	0.805	0.925	0.13	0.0029	0.0096
rs1261117	18	52949657	TC	1.153	1.225	1.166	9.3×10–4	0.026	8.21×10–5
rs1564483	18	60794654	GA	1.038	1.150	1.054	0.069	0.0045	0.0056
rs4892046	18	70484496	GA	1.021	1.151	1.036	0.21	0.0025	0.027
rs12611334	19	40229409	GC	1.038	1.152	1.048	0.037	0.0087	0.005
rs16939	19	46276056	CA	1.031	1.113	1.041	0.076	0.0147	0.011
rs10483204	22	40870794	TC	1.134	1.156	1.138	5.90×10–6	0.0093	1.91×10–7
rs10483205	22	40883599	TC	0.877	0.856	0.874	3.99×10–6	0.014	1.86×10–7
rs12159787	22	40870699	GA	0.883	0.861	0.878	7.51×10–6	0.0062	1.56×10–7
rs138866	22	50205903	GA	0.933	0.865	0.925	0.0010	0.015	8.94×10–5
rs138880	22	50218611	CA	1.072	1.187	1.086	0.0010	0.0029	4.01×10–5
rs16985899	22	40963402	TC	0.874	0.854	0.871	1.67×10–6	0.010	5.64×10–8
rs17001977	22	40880213	GA	1.139	1.163	1.143	4.81×10–6	0.014	2.27×10–7
rs17001993	22	40900077	GA	1.139	1.168	1.144	4.24×10–6	0.012	1.64×10–7
rs17001997	22	40905072	GA	1.139	1.168	1.144	4.54×10–6	0.012	1.84×10–7
rs17002024	22	40975268	TC	0.878	0.853	0.873	2.46×10–6	0.0065	5.81×10–8
rs17002026	22	40982581	TC	0.878	0.854	0.873	2.21×10–6	0.0067	5.34×10–8
rs17002027	22	40984571	TC	1.145	1.178	1.151	1.40 × 10 –6	0.0076	3.98 × 10 –8
rs17002030	22	40989374	TC	1.147	1.173	1.151	9.35 × 10 –7	0.0096	2.92 × 10 –8
rs17002034	22	40996367	TG	0.873	0.850	0.869	1.40 × 10 –6	0.0082	4.08 × 10 –8
rs17002038	22	41000964	TC	0.874	0.853	0.870	1.53×10–6	0.0099	5.39×10–8
rs3827381	22	40881402	TC	1.131	1.154	1.136	1.55×10–5	0.010	5.26×10–7
rs3827382	22	40881403	GA	1.138	1.163	1.143	7.94×10–6	0.014	3.61×10–7
rs5749683	22	34252374	TC	0.924	0.868	0.915	2.2×10–4	0.0053	7.11×10–6
rs5995867	22	40888136	TG	1.135	1.160	1.140	5.37×10–6	0.0076	1.37×10–7
rs5995871	22	40922332	GA	0.879	0.850	0.873	2.87×10–6	0.0054	6.31×10–8
rs5995886	22	41033801	GA	1.102	1.139	1.108	4.02×10–6	0.0076	1.21×10–7
rs6001912	22	40828361	TC	1.138	1.158	1.142	4.74×10–6	0.0092	1.4×10–7
rs6001930	22	40876234	TC	1.133	1.154	1.137	6.84×10–6	0.010	2.23×10–7
rs6001931	22	40877514	GA	1.133	1.155	1.138	6.88×10–6	0.0099	2.24×10–7
rs6001946	22	40903421	GA	0.882	0.876	0.880	6.38 × 10 –6	0.0009	2.04 × 10 –8
rs6001974	22	40979164	GA	0.877	0.850	0.872	2.18 × 10 –6	0.0053	4.16 × 10 –8
rs6001980	22	41004384	TC	1.140	1.172	1.146	2.02 × 10 –6	0.0061	4.60 × 10 –8
rs6001981	22	41017425	TC	0.876	0.854	0.872	1.79 × 10 –6	0.0069	4.66 × 10 –8

^aThe OR is based on reference alleles.

^bTwo-tailed P values.

^cA₁₂, reference and alternative alleles.

^dPGC + SWE case-control samples consisted of 13833 cases and 18310 controls.

^eThe family-based samples are from 3 different subsamples with a total of 6283 subjects.

^fMeta-analysis results for the case-control and family-based samples. Meta-analysis was performed based on a fixed-effects model. SNPs reached genome-wide significance level in PGC + SWE case-control sample are in italics. Genome-wide significant P values (P < 5.0 × 10^–8) in the combined samples are shown in bold.