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. 2012 Dec 13;16(12):2968–2977. doi: 10.1111/j.1582-4934.2012.01624.x

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© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

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Fig 7 — In vitro effects of GW9662 and troglitazone (TGZ) on RANKL mRNA, OPG mRNA, Wnt signalling and protein secretion in mesenchymal stem cells (MSC) from spinal cord injury (SCI) and SHAM rats. (A) TGZ up-regulated RANKL/OPG ratio, whereas GW9662 down-regulated RANKL/OPG ratio in MSCs from SCI rats as compared with that of SHAM rats. And, TGZ down-regulated Wnt1 in MSCs from SCI rats as compared with that of SHAM rats. (B–E) The adiponectin levels in the medium were significantly higher in MSCs from SCI rats than SHAM rats, whereas the ALP and OPG levels were significantly lower in MSCs from SCI rats than SHAM rats. There was no significant difference of leptin levels in the medium between MSCs from SCI rats and SHAM rats. The ALP abd OPG levels in the medium were decreased in MSCs treated with TGZ, and increased in MSCs treated with GW9662. The values of medium levels were pooled from 10 samples per group and expressed as averages ± SE. *P < 0.01.