Table 2. Selected genes induced by HA fragments.
Summary of the various genes that are induced by HA binding in different cell types discussed in this review, and corresponding references.
| Category | Gene | Cell type | References |
|---|---|---|---|
| Cytokines | IL-12 | Macrophages | (Hodge-Dufour et al., 1997) |
| TNF-α | Macrophages | (Jiang et al., 2006) | |
| IL-1β | Macrophages | (Jiang et al., 2006; Feng et al., 2012) | |
| IL-6 | Fibroblasts, Macrophages, B Cells | (Iwata et al., 2009; Yamawaki et al., 2009; Vistejnova et al., 2014) | |
| IL-8 | Fibroblasts, Airway Epithelial Cells, Macrophages, Endothelial Cells | (McKee et al., 1996; Taylor et al., 2004; Boodoo et al., 2006; Vistejnova et al., 2014) | |
| IL-10 | Regulatory T Cells, B Cells | (Bollyky et al., 2009; Iwata et al., 2009; Bollyky et al., 2011) | |
| IFNβ | Macrophages | (Black et al., 2013) | |
| Chemokines | MIP-α | Macrophages | (Hodge-Dufour et al., 1997) |
| KC | Macrophages | (Horton et al., 1998) | |
| MCP-1 | Macrophages | (Yamawaki et al., 2009) | |
| CXCL2 | Macrophages | (Jiang et al., 2005) | |
| CCL5 | Macrophages | (McKee et al., 1996) | |
| CXCL9 | Macrophages | (Horton et al., 1998) | |
| CXCL10 | Macrophages | (McKee et al., 1996; Horton et al., 1998) | |
| CXCL1 | Endothelial Cells | (Takahashi et al., 2005) | |
| CCL3 | Macrophages | (McKee et al., 1996) | |
| CCL4 | Macrophages | (McKee et al., 1996) | |
| ECM | MMP-9 | Fibroblasts, Macrophages, Dendritic Cells | (Fieber et al., 2004; Stern et al., 2006) |
| MMP-13 | Fibroblasts | (Fieber et al., 2004; Stern et al., 2006) | |
| MMP-10 | Endothelial Cells | (Stern et al., 2006) | |
| PAI-1 | Macrophages | (Horton et al., 2000) | |
| uPA | Macrophages | (Horton et al., 2000) | |
| MME | Macrophages | (Horton et al., 1999) | |
| Transcription factors | NF-kappa B | Dendritic Cells | (Fieber et al., 2004) |
| IκBα | Macrophages | (Noble et al., 1996) | |
| AP-1 | Endothelial Cells | (Deed et al., 1997) | |
| Growth factors | TGF-β1 | Eosinophils, Macrophages, B cells | (Ohkawara et al., 2000; Iwata et al., 2009; Tolg et al., 2014) |
| TGF-β2 | Monocytes | (Taylor et al., 2007) | |
| IGF-1 | Macrophages | (Noble et al., 1993) | |
| Others | cPLA2α | Monocytes, Macrophages | (Sokolowska et al., 2014) |
| c-jun | Endothelial Cells | (Wang et al., 2011) | |
| c-fos | Endothelial Cells | (Wang et al., 2011) | |
| Cdc2 (Cdk1) | Endothelial Cells | (Matou-Nasri et al., 2009) | |
| Src | Endothelial Cells | (Wang et al., 2011) | |
| iNOS | Hepatocytes, Endothelial Cells | (Rockey et al., 1998) | |
| MDR-1 | Lymphocytes | (Tsujimura et al., 2006) |