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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Mol Cell Neurosci. 2015 Jan 20;65:11–20. doi: 10.1016/j.mcn.2015.01.001

Figure 2. HIV+sup- and morphine-mediated interactive effects on GSK3β-activation.

Figure 2

At 12, 24, and 72 h after treatments, cells were lysed and immunoblotted for p-GSKβ-S9 and t-GSK3β. Findings were reported as average levels of p-GSKβ-S9 normalized with t-GSK3β (p-GSKβ-S9/t-GSK3β) as a percentage of control values ± SEM. Significance was analyzed by one-way ANOVA and Duncan’s post hoc test; n = 4 separate experiments. At all time points, HIV+sup significantly reduced p-GSK3β-S9 (*p < 0.05 vs. Control). At 24 and 72 h, morphine alone also induced significant loss of p-GSK3β-S9, but a significant interaction with HIV+sup was seen only at 24 h ($p < 0.05). Control = controlsup; HIV = HIV+sup; Mor = morphine.