. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Diabetologia. 2015 Jan 27;58(5):988–996. doi: 10.1007/s00125-015-3498-7

Table 5.

Indirect effect of parental diabetes mediated by individual mediators in models unadjusted for GRS (above) and adjusted for GRS (below)

Base model	Mediator	Indirect effect, OR (95% CI)	Proportion mediated, % (95% CI)	p value
Age, sex	MSS	1.20 (1.07, 1.33)	21.0 (7.8, 32.9)	0.001
	HOMA-IR	1.13 (1.04, 1.22)	14.4 (4.6, 23.5)	0.002
	CIR	1.02 (0.98, 1.06)	2.6 (−2.6, 7.6)	0.26
	GRS	1.07 (1.03, 1.12)	8.9 (3.9, 14.9)	0.002
Age, sex, GRS	MSS	1.18 (1.06, 1.32)	20.5 (7.2, 34.4)	0.003
	HOMA-IR	1.14 (1.05, 1.23)	16.8 (6.3, 26.6)	0.002
	CIR	1.01 (0.98, 1.05)	1.4 (−2.9, 7.0)	0.35