Akt2 null mice have mildly reduced adiposity and equivalent levels of adipokines to wild-type mice. All experiments were done in randomly fed, 10–12-week old, wild-type (black bars) or Akt2 null (white bars) male mice. (a) Weight in grams, n=19 for both genotypes. (b) Fat/lean mass % as measured by NMR, n=5 for both genotypes. (c) Inguinal fat and (d) epididymal fat pad weights in grams, n=5 for both genotypes. (e) Serum leptin, (f) adiponectin, (g) resistin and (h) TNF-α levels, n=19 for both genotypes. Data are expressed as means ± SEM. *p<0.05, as indicated. WT, wild-type