Altered glucose homeostasis with normal suppression of lipolysis in refed Akt2 null mice. Wild-type (black bars) or Akt2 null (white bars) male mice, 10–12 weeks old, were fasted overnight (16 h) and refed for 2 h. Serum levels of (a) glucose (n=20), (b) insulin (n=20), (c) glycerol (n=20), (d) NEFA (n=10), (e) TG (n=9–10) and (f) ketones (n=9–10) were measured and expressed as means ± SEM. *p<0.05, **p<0.01, as indicated. WT, wild-type