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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Trends Immunol. 2015 Mar 12;36(4):257–264. doi: 10.1016/j.it.2015.02.007

Figure 3. Immune checkpoint blockade may regulate metabolic reprogramming of T cells.

Figure 3

Blockade of PD-1 and CTLA4 may increase the metabolic fitness of Teff by enhancing the activity of PI3K/Akt/mTor and increasing cMyc expression that then stimulate aerobic glycolysis and anabolic metabolism. AA, amino acids; FA, fatty acids; Costim, costimulation.