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. Author manuscript; available in PMC: 2016 Apr 30.
Published in final edited form as: J Neurosci Methods. 2015 Feb 14;245:25–36. doi: 10.1016/j.jneumeth.2015.02.005

Figure 7. Projection images of arrays (~20 sections each) from external capsule labeled with the axonal injury marker SMI-32-Alexa 594 and tubulin-Alexa 488.

Figure 7

(A, B) Axons from uninjured wild-type mice displayed little SMI-32 labeling. (C,D) Mice subjected to repetitive concussive traumatic brain injury had punctate areas of SMI-32 labeling and occasional colocalization of SMI-32 and tubulin in swollen axons at 7 days. (E,F) Larger axonal varicosities >3 µm in diameter were apparent in a model of 1.5 mm CCI moderate traumatic brain injury at 7 days. Tubulin loss was also evident. Panels in each row represent images of arrays from two separate mice.