Table 2.
Effects of Musa paradisiaca sap on castor oil-induced diarrhoea in Wistar rats.
| Distilled water | Loperamide (mg/kg body weight) | Musa paradisiaca sap (mL) | |||
|---|---|---|---|---|---|
| Parameters/dose (mL) | 0 | 2.5 | 0.25 | 0.5 | 1.0 |
|
| |||||
| Onset time (min) | 63.10 ± 1.60a | 122.30 ± 3.74b | 72.30 ± 2.62c | 97.40 ± 2.61d | 134.50 ± 2.62e |
| Total number of feaces | 5.11 ± 0.74a | 2.11 ± 0.59b | 3.89 ± 0.90c | 2.82 ± 0.26d | 2.30 ± 0.71b |
| Number of wet feaces | 4.33 ± 0.47a | 0.80 ± 0.12b | 1.94 ± 0.37c | 0.94 ± 0.13d | 0.67 ± 0.06e |
| Fresh weight of feaces (g) | 3.71 ± 0.21a | 0.71 ± 0.05b | 2.14 ± 0.37c | 0.87 ± 0.13d | 0.58 ± 0.02b |
| Water content of feaces | 1.78 ± 0.25a | 0.33 ± 0.06b | 1.08 ± 0.23c | 0.86 ± 0.12c | 0.36 ± 0.04b |
| Inhibition of defecation (%) | 0 | 58.70 | 23.80 | 44.80 | 54.90 |
| Small intestine Na + K + ATPase activity (μmol Pi/mg protein/hour) | 831.16 ± 10.44a | 1012.05 ± 13.68b | 1321.04 ± 13.19c | 1491.48 ± 9.60d | 1610.02 ± 15.11e |
| Small intestine nitric oxide concentration (μmol/L) | 162.14 ± 9.02a | 91.22 ± 7.54b | 92.29 ± 5.36b | 70.09 ± 7.09c | 56.27 ± 4.30d |
Data are mean of six determinations ± SEM. Test values with superscripts b, c, d, and e different from that of the castor oil-induced diarrhoea distilled water treated control, a, across the row for each parameter are significantly different (P < 0.05).