Table 2.
Frequencies of HLA alleles between the two cohorts of blood donors a
| Loci | 4-digit | HCV infected donors n (%) |
Uninfected donors n (%) |
P value | OR (95% CI) |
|---|---|---|---|---|---|
| HLA-A | 01:01 | 10 (1.2) | 19 (1.5) | 0.648 | 0.892(0.539,1.478) |
| 02:01 | 49 (6.1) | 0.648 | 0.334 | 0.894(0.709,1.129) | |
| 02:03 | 66 (8.2) | 120 (9.3) | 0.364 | 0.913(0.746,1.117) | |
| 02:06 | 23 (2.8) | 48 (3.7) | 0.276 | 0.835(0.594,1.174) | |
| 02:07 | 98(12.1) | 135 (10.5) | 0.247 | 1.103(0.938,1.296) | |
| 03:01 | 14 (1.7) | 11 (0.9) | 0.072 | 1.460(1.027,2.075) | |
| 11:01 | 244 (30.2) | 423 (32.8) | 0.199 | 0.926(0.822,1.043) | |
| 11:02 | 32 (4.0) | 34 (2.6) | 0.093 | 1.267(0.982,1.635) | |
| 24:02 | 125 (15.5) | 187 (14.5) | 0.559 | 1.046(0.902,1.212) | |
| 26:01 | 14 (1.7) | 26 (2.0) | 0.639 | 0.906(0.592,1.386) | |
| 29:01 | 5 (0.6) | 26 (2.0) | 0.010 | 0.414(0.185,0.927) | |
| 30:01 | 27 (3.3) | 24 (1.9) | 0.033 | 1.385(1.063,1.805) | |
| 31:01 | 14 (1.7) | 9 (0.7) | 0.027 | 1.588(1.139,2.214) | |
| 33:03 | 88 (10.9) | 134 (10.4) | 0.731 | 1.031(0.868,1.224) | |
|
| |||||
| HLA-B b | 07:05 | 4 (0.6) | 30 (2.7) | 0.001 ** | 0.299(0.119,0.752) |
| 13:01 | 63 (8.8) | 105 (9.3) | 0.708 | 0.962(0.784,1.180) | |
| 13:02 | 25 (3.5) | 18 (1.6) | 0.009 * | 1.515(1.168,1.965) | |
| 15:01 | 21 (2.9) | 14 (1.2) | 0.010 * | 1.561(1.184,2.059) | |
| 15:02 | 61 (8.5) | 136 (12.0) | 0.016 * | 0.778(0.627,0.967) | |
| 27:04 | 9 (1.3) | 25 (2.2) | 0.135 | 0.677(0.386,1.190) | |
| 35:01 | 18 (2.5) | 16 (1.4) | 0.089 | 1.372(0.994,1.894) | |
| 38:02 | 35 (4.9) | 63 (5.6) | 0.514 | 0.915(0.697,1.202) | |
| 39:01 | 13 (1.8) | 14 (1.2) | 0.317 | 1.244(0.838,1.848) | |
| 40:01 | 135 (18.8) | 192 (17.0) | 0.318 | 1.078(0.933,1.245) | |
| 40:02 | 9 (1.3) | 21 (1.9) | 0.316 | 0.769(0.444,1.333) | |
| 46:01 | 131 (18.3) | 196 (17.4) | 0.618 | 1.038(0.897,1.203) | |
| 48:01 | 14 (2.0) | 18 (1.6) | 0.565 | 1.129(0.759,1.679) | |
| 51:01 | 34 (4.7) | 58 (5.1) | 0.704 | 0.949(0.722,1.247) | |
| 51:02 | 12 (1.7) | 20 (1.8) | 0.875 | 0.965(0.615,1.515) | |
| 54:01 | 27 (3.8) | 43 (3.8) | 0.962 | 0.993(0.734,1.342) | |
| 55:02 | 20 (2.8) | 37 (3.3) | 0.555 | 0.901(0.630,1.288) | |
| 58:01 | 86 (12.0) | 123 (10.9) | 0.467 | 1.068(0.898,1.269) | |
|
| |||||
| HLA-DRB1 | 03:01 | 64 (8.3) | 95 (7.4) | 0.472 | 1.077(0.883,1.313) |
| 04:03 | 19 (2.5) | 43 (3.4) | 0.251 | 0.810(0.555,1.184) | |
| 04:05 | 42 (5.4) | 68 (5.3) | 0.896 | 1.016(0.796,1.298) | |
| 04:06 | 14 (1.8) | 20 (1.6) | 0.664 | 1.097(0.731,1.646) | |
| 07:01 | 47 (6.1) | 58 (4.5) | 0.120 | 1.203(0.965,1.499) | |
| 08:03 | 42 (5.4) | 67 (5.2) | 0.836 | 1.026(0.804,1.310) | |
| 09:01 | 115 (14.9) | 184 (14.3) | 0.739 | 1.027(0.879,1.200) | |
| 10:01 | 9 (1.2) | 38 (3.0) | 0.008 | 0.504(0.279,0.908) | |
| 11:01 | 43 (5.6) | 82 (6.4) | 0.446 | 0.910(0.710,1.167) | |
| 12:01 | 20 (2.6) | 34 (2.7) | 0.931 | 0.985(0.692,1.401) | |
| 12:02 | 78 (10.1) | 162 (12.6) | 0.083 | 0.849(0.701,1.028) | |
| 13:02 | 22 (2.8) | 24 (1.9) | 0.147 | 1.280(0.942,1.740) | |
| 13:12 | 14 (1.8) | 13 (1.0) | 0.124 | 1.386(0.960,2.002) | |
| 14:01 | 47 (6.1) | 60 (4.7) | 0.165 | 1.179(0.945,1.472) | |
| 14:05 | 22 (2.8) | 28 (2.2) | 0.344 | 1.175(0.855,1.615) | |
| 15:01 | 98 (12.7) | 153 (11.9) | 0.614 | 1.044(0.885,1.232) | |
| 15:02 | 37 (4.8) | 50 (3.9) | 0.332 | 1.138(0.885,1.462) | |
| 16:02 | 40 (5.2) | 104 (8.1) | 0.012 | 0.725(0.553,0.949) | |
a
Alleles with frequencies higher than 1.0% were shown at the 4-digit level and analyzed.
b
Alleles with statistical significance (q<0.1) were indicated in bold.
*
q < 0.1;
**
q <0.05