Figure 3. AZD1480-mediated tumor growth inhibition is accompanied by reduced STAT3 activation.

(A) Gross images of reproductive tracts and light microscopic images of hematoxylin and eosin (H&E) and TAg stained sections of tumors from representative vehicle- (upper panels) or AZD1480-treated (lower panels) mice. Tumor tissue specimens from vehicle- and AZD1480-treated mice were harvested 6 hours after the last drug dose and analyzed by immunoblot (B) and electro chemiluminescent ELISA analysis (C) for detection and quantification of activating STAT3 phosphorylation at tyrosine 705 (pSTAT3^Y705). ****p<0.0001.