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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Mol Cancer Ther. 2015 Feb 2;14(4):1035–1047. doi: 10.1158/1535-7163.MCT-14-0800

Figure 6. AZD1480-mediated JAK/STAT3 inhibition reduces T cell populations in the peritoneal tumor microenvironment.

Figure 6

Cell suspensions were prepared from peritoneal washes and spleens harvested from vehicle- (n=12) and AZD1480-treated (n=19) mice and analyzed by flow cytometry. A) Representative flow cytometry dot plots and pooled data showing the number and percent (normalized to CD45+ leukocytes) of CD45+CD4+ T cells in peritoneal cavity and spleen. B) Representative flow cytometry dot plots and pooled data showing the absolute number and percent (normalized to CD45+ leukocytes) of CD45+CD4+FoxP3+ T cells in peritoneal cavity and spleen. Bars show mean ±SEM (Vehicle: n=10; AZD1480: n =19). Statistical analysis is based on Wilcoxon test, *p<0.05, ** p <0.01.