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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Mol Cancer Ther. 2015 Apr;14(4):920–930. doi: 10.1158/1535-7163.MCT-14-0474

Figure 1. Blood brain barrier (BBB) permeability studies demonstrate compromised BBB in tumors as compared to normal brain and no significant differences in BBB permeability between models.

Figure 1

(A) Relative enhancement of four tumor cell lines with matched normal, tumor, and choroid plexus as determined from T1 DCE MR images, formed from digitally subtracting pre-contrast T1-DCE-weighted sequence from the identical sequence performed after gadolinium administration (20th sequence). Significant difference was observed between tumor and normal brain tissue (p<0.001), and no significant difference was seen between models within each tissue type (p>.14 within each tissue). (B) Brain MR imaging of a preresentative intracranial tumor from each of the four intracranial models.