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. 2015 Apr 14;21(14):4323–4333. doi: 10.3748/wjg.v21.i14.4323

Table 3.

Bivariate estimates of diagnostic precision based on different carbohydrate antigen 19-9 assay methods and cut-off values

Assay method or cut-off value Number of studies Number of participants Sensitivity (95%CI) Specificity (95%CI) PLR (95%CI) NLR (95%CI) DOR (95%CI)
ELISA 11 1396 0.83 (0.80-0.86) 0.79 (0.75-0.82) 3.97 (2.96-5.33) 0.20 (0.15-0.28) 22.64 (12.44-41.22)
RIA 17 3074 0.82 (0.80-0.84) 0.81 (0.79-0.83) 4.16 (3.09-5.60) 0.23 (0.19-0.27) 20.14 (13.27-30.55)
EIA 3 427 0.75 (0.70-0.80) 0.79 (0.70-0.86) 3.84 (1.82-8.10) 0.34 (0.27-0.43) 10.29 (4.96-21.34)
LIA 2 224 ND ND ND ND ND
Cut-off of 37 U/mL 30 4879 0.82 (0.80-0.83) 0.80 (0.78-0.82) 3.94 (3.24-4.78) 0.24 (0.21-0.28) 18.79 (13.67-25.82)
Cut-off of 100 U/mL 3 297 0.69 (0.61-0.76) 0.85 (0.79-0.91) 4.35 (2.86-6.61) 0.38 (0.18-0.77) 11.53 (4.47-29.77)
All studies 34 5115 0.81 (0.80-0.83) 0.81 (0.79-0.82) 4.08 (3.39-4.91) 0.24 (0.21-0.28) 19.31 (14.40-25.90)

DOR: Diagnostic odds ratio; EIA: Enzyme immunoassay; ELISA: Enzyme-linked immunosorbent assay; LIA: Luminescent immunoassay; ND: Not done; NLR: Negative likelihood ratio; PLR: Positive likelihood ratio; RIA: Radioimmunoassay.