Table 2.
Association Analysis of Genotypes of SNP of IL-1 Gene with Chronic Periodontitis
| SNP in IL-1 gene | Controls (n=200) | Chronic periodontitis (n=200) | OR (95% CI) | p-Value |
|---|---|---|---|---|
| (rs1800587) IL1A −889 C>T | ||||
| CC | 107 (53.5) | 104 (52.0) | Ref | |
| CT | 79 (39.5) | 79 (39.5) | 1.029 (0.68–1.55) | 0.892 |
| TT | 14 (7.0) | 17 (8.5) | 1.25 (0.59–2.66) | 0.564 |
| CT+TT | 93 (46.5) | 96 (48.0) | 1.062 (0.72–1.57) | 0.764 |
| HWE (p-value) | 0.911 | 0.717 | ||
| (rs17561) IL1A +4845 G>T | ||||
| GG | 101 (50.5) | 96 (48.0) | Ref | |
| GT | 75 (37.5) | 81 (40.5) | 1.14 (0.75–1.73) | 0.551 |
| TT | 24 (12.0) | 23 (11.5) | 1.01 (0.53–1.91) | 0.980 |
| GT+TT | 99 (49.5) | 104 (52.0) | 1.11 (0.75–1.64) | 0.617 |
| HWE (p-value) | 0.091 | 0.354 | ||
| (rs16944), IL1B −511C>T | ||||
| CC | 97 (48.5) | 83 (41.5) | Ref | |
| CT | 82 (41.0) | 86 (43.0) | 1.23 (0.80–1.87) | 0.344 |
| TT | 21 (10.5) | 31 (15.5) | 1.73 (0.92–3.23) | 0.088 |
| CT+TT | 103 (51.5) | 117 (58.5) | 1.33 (0.89–1.97) | 0.160 |
| HWE (p-value) | 0.556 | 0.272 | ||
| rs1143634, IL1B +3954C>T | ||||
| CC | 130 (65.0) | 103 (51.5) | Ref | |
| CT | 66 (33.0) | 92 (46.0) | 1.76 (1.17–2.65) | 0.007* |
| TT | 4 (2.0) | 5 (2.5) | 1.58 (0.41–6.03) | 0.505 |
| CT+TT | 70 (35.0) | 97 (48.5) | 1.75 (1.17–2.61) | 0.006* |
| HWE (p-value) | 0.182 | 0.003 | ||
| IL1RN VNTR | ||||
| a1a1 | 127 (63.5) | 137 (68.5) | Ref | |
| Rest all | 73 (36.5) | 63 (31.5) | 0.80 (0.524–1.21) | 0.292 |
| HWE (p-value) | <0.001 | <0.001 | ||
*
Bold indicates p-value<0.05, statistically significant.
95% CI, 95% confidence interval; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; SNP, single nucleotide polymorphism; VNTR, variable number of tandem repeat.