FIG. 1.

Schematic of proposed methods. The main modules are linear regression analyses of rs-fcMRI estimate strengths within specific functional networks against the CBF-BOLD coupling (case I) and macrovascular volume fraction (case II). Regionally specific functional connectivity strengths are assessed by calculating the sum of connectivity strengths in major nodes of predefined resting-state networks. For this purpose, they selected the default mode network, frontoparietal network, and primary sensory-motor network. BOLD, blood oxygenation level-dependent; CBF, cerebral blood flow.