FIG. 5.

Macrovascular volume fraction derived from the MNI digital brain phantom, and its associations with functional connectivity strength. (a) Vessels in the digital brain phantom (Aubert-Broche et al., 2006) were imaged by using Proton Density-weighted MRI, and MR angiography, and then segmented by using a multiscale geometric flow-based method. Segmented vessels include superficial vessels as well as penetrating vessels. The scatter plots depict the negative linear relationship between samples of macrovascular volume fraction and connectivity strengths averaged across all voxels of ROIs involved in (b) default mode networks, (c) frontoparietal network, and (d) primary sensory-motor cortex.