Table 3.

Additional Information Provided by the Indicated Methods Compared with Optimized Correlation

Method	TI shared with correlation	TI unique to correlation	TI discovery unique to correlation (ratio)	TI unique to other method	TI discovery unique to other method (ratio)
ARACNE	49	35	0.60	9	0.11
GENIE3	72	12	0.14	13	0.15
TIGRESS	65	19	0.24	13	0.15

The last column shows the ratio of newly identified TI to those found with the correlation method. This column shows that adding an additional method increases the number of validated interactions (TI) already found with optimized correlation only by 11–15%. The third data column shows the same ratio when optimized correlation is added to one of the other three methods.