Table 3.
Logistic regression modeling results
| All subjects (n = 715) | |||||
| Model | Outcome | Covariates | Odds ratio | 95% CI | p-value |
| 1 | control vs SIM (mild and severe) | none | 1.14 | (0.82–1.61) | 0.437 |
| 2 | control vs SIM (mild and severe) | age + sex | 1.17 | (0.78–1.77) | 0.447 |
| 4 | control vs mild SIM only | none | 1.11 | (0.79–1.58) | 0.548 |
| 5 | control vs mild SIM only | age + sex | 1.15 | (0.75–1.77) | 0.517 |
| 6 | control vs severe SIM only | none | 1.18 | (0.81–1.72) | 0.382 |
| 7 | control vs severe SIM only | age + sex | 1.19 | (0.76–1.85) | 0.453 |
| Subjects without potentially confounding medications (n = 386) | |||||
| Model | Outcome | Covariates | Odds ratio | 95% CI | p-value |
| 8 | control vs SIM (mild and severe) | none | 0.90 | (0.60–1.34) | 0.598 |
| 9 | control vs SIM (mild and severe) | age + sex | 1.00 | (0.61–1.62) | 0.982 |
| 11 | control vs mild SIM only | none | 0.93 | (0.61–1.42) | 0.737 |
| 12 | control vs mild SIM only | age + sex | 1.06 | (0.63–1.77) | 0.833 |
| 13 | control vs severe SIM only | none | 0.86 | (0.55–1.36) | 0.523 |
| 14 | control vs severe SIM only | age + sex | 0.91 | (0.53–1.57) | 0.740 |
| Propensity-matched dataset (n = 188) | |||||
| Model | Outcome | Covariates | Odds ratio | 95% CI | p-value |
| 15 | control vs SIM (mild and severe) | none | 1.19 | (0.74–1.90) | 0.475 |
| 16 | control vs SIM (mild and severe) | age + sex | 1.33 | (0.75–2.36) | 0.338 |
| 17 | control vs mild SIM only | none | 1.23 | (0.70–2.16) | 0.482 |
| 18 | control vs mild SIM only | age + sex | 1.70 | (0.80–3.60) | 0.170 |
| 19 | control vs severe SIM only | none | 1.08 | (0.61–1.88) | 0.800 |
| 20 | control vs severe SIM only | age + sex | 1.17 | (0.60–2.28) | 0.648 |
CI = confidence interval; SIM = statin-induced myopathy