Table 2. Top overlapping gene ontology pathways.
| GO term (biological process) | Old | 1 mo post DSB | 2 mo post DSB |
|---|---|---|---|
| Up regulated | |||
| T-cell activation (GO: 0042110) | 9.4 × 10−13 | 5.2 × 10−11 | 2.0 × 10−3 |
| Immune response (GO: 0006955) | 2.2 × 10−18 | 2.8 × 10−8 | NA |
| Cell activation (GO: 0001775) | 5.5 × 10−18 | 4.6 × 10−8 | NA |
| Chemotaxis (GO: 0006935) | 3.0 × 10−6 | 2.8 × 10−7 | 1.5 × 10−3 |
| T-cell proliferation (GO: 0042098) | 2.0 × 10−6 | 1.8 × 10−6 | 1.3 × 10−3 |
| Integrin-mediated signalling pathway (GO: 0007229) | 3.4 × 10−4 | 9.0 × 10−6 | 2.8 × 10−3 |
| Lymphocyte proliferation (GO: 0046651) | 3.0 × 10−5 | 2.1 × 10−5 | 4.1 × 10−3 |
| Leukocyte proliferation (GO: 0070661) | 3.9 × 10−5 | 2.4 × 10−5 | 4.4 × 10−3 |
| Mononuclear cell proliferation (GO: 0032943) | 3.9 × 10−5 | 2.4 × 10−5 | 4.4 × 10−3 |
| Cell cycle (GO: 0007049) | 1.0 × 10−4 | 3.2 × 10−5 | 2.0 × 10−2 |
| Cell proliferation (GO: 008283) | 5.1 × 10−5 | 1.5 × 10−4 | 1.2 × 10−2 |
| Regulation of apoptosis (GO: 0042981) | 2.0 × 10−3 | 6.3 × 10−3 | NA |
| Cell adhesion (GO: 0007155) | 1.8 × 10−5 | 1.8 × 10−3 | NA |
| Regulation of actin filament polymerization (GO: 0030833) | 1.5 × 10−2 | 3.3 × 10−3 | NA |
| Down regulated | |||
| Acute inflammatory response (GO: 0002526) | 1.2 × 10−2 | 1.7 × 10−5 | NA |
| Steroid metabolic process (GO: 0008202) | 3.7 × 10−3 | 2.2 × 10−4 | NA |
| Glucose metabolic process (GO: 0006006) | 1.9 × 10−2 | 2.9 × 10−3 | NA |
| Monosaccharide metabolic process (GO: 0005996) | 1.6 × 10−2 | 3.2 × 10−3 | 1.0 × 10−2 |
| Lipid biosynthetic process (GO: 0008610) | 1.7 × 10−6 | 8.3 × 10−3 | NA |
DSB, double-strand break; GO, gene ontology; mo, months; NA, not available.
The top 10 upregulated and top five downregulated overlapping gene ontology annotations for biological processes for 1 mo post DSB or 2 mo post DSB were compared with old for upregulated and downregulated transcripts. P values were determined using Fisher's exact test.