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Effects of MLN8237 in BCR-ABL+ cells
| Apoptosis | Cell cycle |
|---|---|
| Activation of caspases-9 and -3 | Accumulation of aneuploid cells |
| Decreased expression of Apollon | Inhibition of colony formation |
| Increased expression of Smac | Mitotic slippage |
| Induction of TUNEL+ | Monopolar mitotic spindles |
| DNA fragmentation | Chromatin bridging |
