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. 2015 Mar 23;112(14):4483–4488. doi: 10.1073/pnas.1421758112

Fig. 2.

Fig. 2.

β-Arrestin2 is required for postreactivation restabilization of ORM and spatial memory. Arrb2+/+ and Arrb2−/− mice were tested for ORM retention 48 h after training with (A) or without memory reactivation (B), or tested 1 h after memory reactivation (C). **P < 0.01, ***P < 0.001 vs. (A+B) within the same genotype. (D) Reconsolidation of ORM after postreactivation carvedilol treatment in Arrb2−/− mice (3.0 mg/kg, i.p.). (E and F) Reconsolidation of spatial memory. Mice were trained to find the hidden platform in the Morris water maze; two probe trials were performed sequentially with the platform removed, and the percentage of time spent in each quadrant was calculated. Probe Test 1 (memory reactivation) was carried out 24 h after the last training trial. Probe Test 2 was performed 24 h (E) or 1 h (F) after Probe Test 1. Quadrants: L, left; O, opposite; R, right; T, target. n = 6–10 per group; *P < 0.05 vs. O, L, and R in each probe test, three-way ANOVA.