Table 1.

Plasma and urine electrolyte levels in claudin-8 KO and its control animals

Group	CLDN8flox/flox	CLDN8flox/flox/Aqp2Cre	Significance (n = 15)
Weight, g	21.78 ± 0.53	20.52 ± 0.51	n.s.
Urinary volume, μL/24 h per gram	52.05 ± 5.75	69.56 ± 3.26	P = 0.008
UOsm, Osm/kg	1.463 ± 0.085	1.435 ± 0.097	n.s.
CCr, mL/24 h per gram	3.51 ± 0.45	3.59 ± 0.24	n.s.
Mean BP, mmHg	109.9 ± 4.5	92.3 ± 1.7	P = 0.0007
pH	7.47 ± 0.01	7.46 ± 0.02	n.s.
PHCO3, mmol/L	22.4 ± 0.7	25.3 ± 0.7	P = 0.014
PAldo, pg/mL	370.3 ± 37.8	549.4 ± 29.9	P = 0.005
PCl, mmol/L	106.0 ± 0.91	102.7 ± 0.82	P = 0.017
PNa, mmol/L	141.6 ± 1.4	140.6 ± 1.0	n.s.
PK, mmol/L	4.21 ± 0.10	3.90 ± 0.07	P = 0.016
FECl, %	1.12 ± 0.16	1.93 ± 0.21	P = 0.013
ECl, μmol/24 h per gram	3.93 ± 0.71	6.55 ± 0.65	P = 0.016
FENa, %	0.89 ± 0.09	1.33 ± 0.13	P = 0.020
ENa, μmol/24 h per gram	4.05 ± 0.42	6.10 ± 0.52	P = 0.008
FEK, %	12.60 ± 1.72	22.07 ± 3.04	P = 0.021
EK, μmol/24 h per gram	1.76 ± 0.27	2.94 ± 0.29	P = 0.014

n.s., not significant.