Table 3. Odds ratios of different genetic model comparisons for each single-nucleotide polymorphism associated with essential hypertension in the northern Han Chinese population.
| SNP | Genetic models | Contrast | Overall |
Male* |
Female* |
|||
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | |||
| C825T | Additive | TT vs. CT vs. CC | 1.076 (0.826−1.402) | 0.587 | 1.022 (0.745−1.401) | 0.895 | 1.259 (0.744−2.129) | 0.391 |
| Dominant | (TT + CT) vs.CC | 0.960 (0.637−1.449) | 0.847 | 1.052 (0.647−1.712) | 0.838 | 0.749 (0.333−1.685) | 0.485 | |
| Recessive | TT vs. (CT + CC) | 0.850 (0.542−1.332) | 0.479 | 0.881 (0.510−1.520) | 0.648 | 0.869 (0.347−2.176) | 0.764 | |
| C1429T | Additive | TT vs. CT vs. CC | 1.221 (0.877−1.699) | 0.237 | 1.637 (0.857−3.128) | 0.136 | 0.738 (0.308−1.770) | 0.496 |
| Dominant | (TT + CT) vs.CC | 0.819 (0.561−1.195) | 0.301 | 1.047 (0.667−1.642) | 0.843 | 0.507 (0.236−1.090) | 0.082 | |
| Recessive | TT vs. (CT + CC) | 0.624 (0.216−1.802) | 0.383 | 0.468 (0.114−1.920) | 0.292 | 0.938 (0.164−5.382) | 0.943 | |
| G (-350)A | Additive | AA vs. AG vs.GG | 1.032 (0.402−2.653) | 0.947 | 0.800 (0.284−2.256) | 0.673 | 2.730 (0.206−36.252) | 0.447 |
| Dominant | (AA + AG) vs. GG | 0.969 (0.377−2.489) | 0.947 | 1.250 (0.443−3.524) | 0.673 | 0.366 (0.028−4.864) | 0.447 | |
CI: confidence interval; OR: odds ratio; R: adjusted for gender, age, BMI, glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, smoking habits and drinking habits; SNP: single-nucleotide polymorphism. *OR adjusted for gender was not conducted in male and female.