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L-PNA:PNA multivalent library and landscape. (a) L-PNA:PNA multivalent library and the associated EC50 values for D2R activity. (b) Multivalent landscape highlighting the relationships between the A (red), B (blue), and C (green) type L-PNA constructs when annealed to various lengths of DNA. Key η values are included and indicate an increase in the individual ligand binding affinity.
