Figure 2.
Inhibition profile of DS-437. (A) DS-437 inhibits the PRMT5–MEP50 complex with an IC50 of 5.9 ± 1.4 μM. (B) Out of 31 human methyltransferases tested, DS-437 also significantly inhibited PRMT7, with an IC50 of 6 ± 0.5 μM (C).
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