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. 2015 Mar 2;6(4):413–418. doi: 10.1021/ml500474d

Table 4. In Vivo PK Data in Mice for Selected Lead JNK Inhibitorsa.

cmpd Cmax (μM, i.v.) AUC (μM·h, i.v.) t1/2 (h, i.v.) Cl (mL/min.kg, i.v.) Vd (L/kg, i.v.) %F
11 1.0 0.7 0.5 33 1.3 66
12 0.6 0.3 0.3 72 1.9 100
13 0.9 0.8 1.1 28 1.8 87
18 1.1 0.7 0.4 33 1.0 43
a

Data were generated from three determinations and dosed at 0.5 mg/kg for i.v. and at 3 mg/kg for p.o.