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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Nat Neurosci. 2015 Mar 16;18(4):582–589. doi: 10.1038/nn.3973

Figure 5. Relationship between prefrontal activity and cortical suppression of competing memories.

Figure 5

(a) Left and right mid-ventrolateral prefrontal cortices (VLPFC) showed stronger univariate activity (p < .001) during early (first half) than during late (second half) selective recall repetitions. (b) The univariate decrease across repetitions in both regions predicted the slope of cortical pattern suppression (ML estimates) in ventral visual cortex (VVC), with larger prefrontal decreases associated with more negative-going slopes of competitor suppression. (c) Whole-brain regression showing areas that, across participants, significantly correlate with the slope of competitor suppression (red) and the slope of target reactivation (black) in ventral visual cortex. Both contrasts are shown at p < .001 (uncorrected). (d) Cortical pattern suppression as a function of PFC engagement, splitting the sample into participants with high and low PFC engagement. Participants with high PFC engagement showed a significant (p < .05) difference in the slope of competitor suppression, and in the level of competitor suppression on the fourth (final) retrieval trial. (e) Error bars in panels (b) and (d) represent SEM across participants for each single measure.