Table 2.
Prevalence of maternal complications among women with and those without sickle cell disease
| Complication | SCD (N = 1,526) |
No SCD, CC+a (N = 21,982) |
No SCD, CC–b (N = 311,840) |
|||||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | p value† | N | % | p value† | |
| Maternal medical complications | ||||||||
| Acute renal failure | 10 | 0.7 | 216 | 0.9 | 0.21 | 313 | 0.1 | <0.0001 |
| Cerebrovascular disorder | 12 | 0.8 | 185 | 0.8 | 0.82 | 312 | 0.1 | <0.0001 |
| Deep vein thrombosis | 30 | 2.0 | 181 | 0.8 | <0.0001 | 799 | 0.3 | <0.0001 |
| Pulmonary embolism | 17 | 1.1 | 118 | 0.5 | 0.004 | 343 | 0.1 | <0.0001 |
| Adult respiratory distress syndrome | 25 | 1.4 | 313 | 1.4 | 0.50 | 630 | 0.2 | <0.0001 |
| Obstetric complications | ||||||||
| Obstetric shock | 24 | 1.6 | 117 | 0.5 | <0.0001 | 470 | 0.2 | <0.0001 |
| Eclampsia | 198 | 13.0 | 5,571 | 25.3 | <0.0001 | 18,189 | 5.8 | <0.0001 |
| Postpartum hemorrhage | 69 | 4.5 | 828 | 3.8 | 0.14 | 9,516 | 3.0 | 0.0009 |
| Placental abruption | 27 | 1.8 | 525 | 2.4 | 0.12 | 4,762 | 1.5 | 0.44 |
| Wound complications | 60 | 3.9 | 930 | 4.2 | 0.57 | 5,351 | 1.7 | <0.0001 |
| Uterine atony, abnormal labor forces | 195 | 12.8 | 2,515 | 11.4 | 0.11 | 38,400 | 12.3 | 0.58 |
| Preterm labor/birth | 361 | 23.7 | 5,181 | 23.6 | 0.94 | 51,920 | 16.6 | <0.0001 |
| Premature rupture of membranes | 74 | 4.9 | 1,072 | 4.9 | 0.96 | 15,410 | 4.9 | 0.87 |
| Major perineal laceration | 28 | 1.8 | 211 | 1.0 | 0.001 | 5,631 | 1.8 | 0.93 |
| Obstetric trauma | 56 | 3.7 | 657 | 3.0 | 0.13 | 14,487 | 4.7 | 0.07 |
| Infectious complications | ||||||||
| Postpartum infection | 69 | 4.5 | 562 | 2.6 | <0.0001 | 6,226 | 2.0 | <0.0001 |
| Endometritis/endomyometritis/metritis | 34 | 2.2 | 266 | 1.2 | 0.0006 | 3,125 | 1.0 | <0.0001 |
| Chorioamnionitis | 119 | 7.8 | 1,305 | 5.9 | 0.003 | 18,330 | 5.9 | 0.002 |
| Pneumonia | 19 | 1.3 | 86 | 0.4 | <0.0001 | 221 | 0.1 | <0.0001 |
| Sepsis | 22 | 1.4 | 127 | 0.6 | <0.0001 | 842 | 0.3 | <0.0001 |
| Urinary tract infection | 131 | 8.3 | 1,439 | 6.6 | 0.002 | 12,693 | 4.1 | <0.0001 |
| Genitourinary tract infection | 106 | 7.0 | 1,053 | 4.8 | 0.0002 | 8,992 | 2.9 | <0.0001 |
| Pyelonephritis | 12 | 0.8 | 133 | 0.6 | 0.38 | 1,114 | 0.4 | 0.005 |
| Intrapartum/postpartum procedures | ||||||||
| Ventilation | 18 | 1.2 | 356 | 1.6 | 0.18 | 1,042 | 0.3 | <0.0001 |
| Transfusion | 197 | 12.9 | 558 | 2.5 | <0.0001 | 3,006 | 1.0 | <0.0001 |
| Cesarean delivery | 661 | 43.3 | 10,613 | 48.3 | 0.0002 | 91,745 | 29.4 | <0.0001 |
| Operative vaginal delivery | 366 | 24.0 | 4,073 | 18.5 | <0.0001 | 86,993 | 27.9 | 0.0007 |
SCD sickle cell disease, CC chronic conditions (diabetes, pulmonary hypertension, essential hypertension, congenital heart defects, cardiomyopathy, lupus, viral hepatitis, epilepsy and hypothyroidism)
†
p value for Chi square test of distribution of variable in SCD group versus distribution in non-SCD group
a
“CC+” denotes women without SCD who had report of a chronic condition any time prior to delivery
b
“CC—” denotes women without report of SCD or a chronic condition