Table 3.
Adjusted prevalence ratios for the association between sickle cell disease and maternal complications
| Complication | No SCD, CC+a |
No SCD, CC–b |
||
|---|---|---|---|---|
| aPRc | 95 % CI | aPRc | 95 % CI | |
| Maternal medical complications | ||||
| Acute renal failure | 0.64 | 0.34–1.21 | 6.42 | 3.42–12.03 |
| Cerebrovascular disorder | 0.85 | 0.47–1.52 | 7.92 | 4.45–14.06 |
| Deep vein thrombosis | 2.47 | 1.67–3.62 | 7.75 | 5.40–11.12 |
| Pulmonary embolism | 1.96 | 1.17–3.28 | 10.27 | 6.33–16.67 |
| Adult respiratory distress syndrome | 1.15 | 0.77–1.74 | 7.95 | 5.28–11.67 |
| Obstetric complications | ||||
| Obstetric shock | 2.67 | 1.71–4.18 | 10.18 | 6.78–15.30 |
| Eclampsia | 0.51 | 0.45–0.59 | 2.25 | 1.98–2.57 |
| Postpartum hemorrhage | 1.21 | 0.95–1.55 | 1.47 | 1.17–1.85 |
| Placental abruption | 0.74 | 0.50–1.09 | 1.14 | 0.79–1.66 |
| Wound complications | 0.99 | 0.76–1.28 | 2.25 | 1.76–2.89 |
| Uterine atony, abnormal labor forces | 0.99 | 0.86–1.14 | 1.04 | 0.92–1.19 |
| Preterm labor/birth | 0.99 | 0.90–1.09 | 1.34 | 1.23–1.45 |
| Premature rupture of membranes | 1.02 | 0.81–1.29 | 0.96 | 0.77–1.20 |
| Major perineal laceration | 1.50 | 1.01–2.22 | 1.01 | 0.70–1.47 |
| Obstetric trauma | 1.04 | 0.79–1.36 | 0.79 | 0.61–1.02 |
| Infectious complications | ||||
| Postpartum infection | 1.47 | 1.15–1.89 | 2.22 | 1.76–2.80 |
| Endometritis/endomyometritis/metritis | 1.46 | 1.02–2.09 | 2.17 | 1.56–3.04 |
| Chorioamnionitis | 1.21 | 1.01–1.46 | 1.31 | 1.10–1.56 |
| Pneumonia | 3.13 | 1.88–5.21 | 17.22 | 10.80–27.44 |
| Sepsis | 2.42 | 1.52–3.85 | 5.25 | 3.45–8.00 |
| Urinary tract infection | 1.23 | 1.03–1.47 | 2.09 | 1.77–2.46 |
| Genitourinary tract infection | 1.33 | 1.09–1.62 | 2.36 | 1.96–2.84 |
| Pyelonephritis | 1.14 | 0.63–2.07 | 2.16 | 1.23–3.81 |
| Intrapartum/postpartum procedures | ||||
| Ventilation | 0.64 | 0.40–1.03 | 3.36 | 2.11–5.33 |
| Transfusion | 5.21 | 4.43–6.12 | 12.37 | 10.84–14.11 |
| Cesarean delivery | 0.94 | 0.88–1.00 | 1.21 | 1.18–1.23 |
| Operative vaginal delivery | 1.45 | 1.34–1.56 | 1.23 | 1.12–1.35 |
SCD sickle cell disease, CC chronic conditions (diabetes, pulmonary hypertension, essential hypertension, congenital heart defects, cardio-myopathy, lupus, viral hepatitis, epilepsy and hypothyroidism)
a
“CC+” denotes women without SCD who had report of a chronic condition any time prior to delivery
b
“CC–” denotes women without report of SCD or a chronic condition
c
Adjusted for maternal age, plurality, and tobacco use ≤40 weeks prior to delivery admission