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. Author manuscript; available in PMC: 2015 Apr 13.
Published in final edited form as: J Am Chem Soc. 2015 Jan 9;137(2):648–651. doi: 10.1021/ja512115s

Table 3.

Robustness screen of the radiosynthesis of [11C]3-aminobenzonitrile with 1 (a) and [Pd(PPh3)4] (b).a

graphic file with name nihms678052t4.jpg
Entry Additive RCC (%) w/ 1a (a) RCC (%) w/ [Pd(PPh3)4]b (b)
1 None 81 30
2 water 80 n.d.
3 phenol 94 25
4 4-methoxybenzamide 88 9
5 pyridine 90 14
6 imidazole 92 0
7 5-fluoroindole 80 n.d.
a

Reaction conditions: 1 (0.002 mmol), additive (0.008 mmol), 3-bromoaniline (0.008 mmol), toluene (0.1 mL), rt, 30 min; then [11C]HCN (1–2 mCi), THF (0.1 mL) rt, 1 min.

b

[Pd(PPh3)4] (0.004 mmol), additive (0.008 mmol), 3-bromoaniline (0.008 mmol), K2CO3 (0.008 mmol), DMF (0.1 mL); then [11C]HCN (1–5 mCi), DMF (0.1 mL), 100 °C, 5 min.

n.d. =not determined.