Table 2.
Automatic Interactive Optimizer (AIO) and clinical plan results
| Plan | Clinical | Nominal AIO | AIO OLD = 25 †† | AIO OLD = 75 †† | AIO 3 objectives/OAR || | AIO 6 objectives/OAR || | AIO T = 7.5s ¶ | AIO T = 30s ¶ | |
|---|---|---|---|---|---|---|---|---|---|
| PTVB V95 * (%) | 99.1 ± 0.2 | 98.9 ± 0.5 | 99.5 ± 0.2 | 97.5 ± 1.2 | 99.2 ± 0.5 | 98.9 ± 0.5 | 98.7 ± 0.6 | 98.5 ± 0.9 | |
| PTVB V107 * (%) | 1.1 ± 1.4 | 1.2 ± 1.6 | 0.5 ± 0.6 | 3.4 ± 3.6 | 0.5 ± 0.7 | 1.1 ± 1.2 | 1.9 ± 1.9 | 1.6 ± 1.6 | |
| PTVE V95 * (%) | 98.2 ± 1.1 | 97.7 ± 0.7 | 98.7 ± 0.6 | 96.0 ± 1.6 | 98.3 ± 1.0 | 97.8 ± 1.0 | 97.4 ± 1.0 | 97.3 ± 1.0 | |
| PTVE V107 * (%) | 14.5 ± 3.8 | 13.0 ± 5.4 | 9.5 ± 4.6 | 16.5 ± 6.2 | 10.3 ± 4.7 | 12.2 ± 5.0 | 13.7 ± 5.6 | 13.6 ± 5.1 | |
| Max dose (Gy) | Spinal Cord | 39.0 ± 3.7 | 39.1 ± 4.1 | 38.3 ± 4.0 | 39.8 ± 3.7 | 38.5 ± 4.2 | 38.8 ± 4.0 | 39.0 ± 3.8 | 38.3 ± 4.9 |
| Brainstem | 37.7 ± 7.7 | 37.3 ± 8.0 | 37.7 ± 8.3 | 38.8 ± 7.8 | 37.0 ± 7.2 | 37.6 ± 8.3 | 37.0 ± 7.9 | 37.5 ± 8.3 | |
| Mean dose (Gy) | Contralateral Parotid | 19.6 ± 5.6 | 18.7 ± 5.7 | 21.4 ± 6.9 | 17.6 ± 5.3 | 21.4 ± 6.7 | 19.5 ± 6.0 | 18.5 ± 5.5 | 19.0 ± 5.9 |
| Ipisilateral Parotid | 31.2 ± 8.1 | 29.9 ± 8.4 | 32.0 ± 8.5 | 27.5 ± 7.1 | 32.1 ± 8.7 | 30.5 ± 8.3 | 29.5 ± 7.9 | 29.8 ± 8.1 | |
| Contralateral Submandibular | 31.2 ± 7.4 | 29.6 ± 8.0 | 34.0 ± 8.6 | 27.7 ± 7.3 | 33.9 ± 8.6 | 30.6 ± 8.3 | 29.4 ± 7.0 | 30.5 ± 7.4 | |
| Oral Cavity | 28.6 ± 7.0 | 24.7 ± 7.9 | 26.7 ± 8.7 | 23.6 ± 7.6 | 27.0 ± 10.3 | 25.6 ± 8.3 | 24.2 ± 6.9 | 26.1 ± 7.4 | |
| Comp sal † | 26.2 ± 5.5 | 25.0 ± 5.8 | 27.7 ± 6.5 | 24.2 ± 5.3 | 27.8 ± 6.2 | 25.8 ± 5.9 | 24.7 ± 5.4 | 25.2 ± 5.7 | |
| Comp swal † | 28.7 ± 8.0 | 23.1 ± 8.7 | 27.0 ± 9.5 | 21.7 ± 8.7 | 26.7 ± 9.5 | 23.8 ± 9.2 | 22.5 ± 8.8 | 23.4 ± 8.7 |
AIO and clinical plan results averaged over all 10 patients using different AIO settings. Clinically acceptable doses to the brainstem and spinal cord were achieved in all plans.
Abbreviations:
*PTVB, PTVE, PTVT: Boost, elective, transition planning target volumes, respectively.
†Compsal / Compswal: Composite salivary glands / Composite swallowing muscles.
††AIO OLD = 25/75: AIO plan using an objective-line distance (OLD) of 25/75 pixels, a pause time of 15 seconds and 9 objectives per OAR.
||AIO 3/6 objectives per OAR: AIO plan using 3/6 objectives per OAR, a pause time of 15 seconds and an OLD of 50 pixels.
¶AIO T = 7.5/30s: AIO plan using pause times (T) of 7.5/30 seconds, 9 objectives per OAR and an OLD of 50 pixels.