Table 1.
Pharmacologic substrates, inhibitors and inducers of cytochrome P450 (CYP2D6) of relevant psychotropic drugs.
| Substrate | Inhibitors | Inducers |
|---|---|---|
| Acetaminophen | Amiodarone | Dexamethasone |
| Amphetamine-Dextroamphetamine | Bupropion | Rifampin |
| Aripiprazole | Celecoxib | |
| Atomoxetine | Chlorpheniramine | |
| Clonidine | Chlorpromazine | |
| Codeine * | Citalopram | |
| Dextromethorphan | Clozapine | |
| Duloxetine | Cocaine | |
| Fluoxetine | Desipramine | |
| Fluvoxamine | Diphenhydramine | |
| Haloperidol | Duloxetine | |
| Iloperidone | Fluoxetine | |
| Methadone | Halofantrine | |
| Methamphetamine | Haloperidol | |
| Mirtazapine | Hydroxychloroquine | |
| Nefazodone | Imatinib | |
| Olanzapine | Imipramine | |
| Paroxetine | Levomepromazine | |
| Phenothiazines | Methadone | |
| Risperidone * | Metoclopramide | |
| Sertraline | Mibefradil | |
| Tricyclic antidepressants (TCAs) | Moclobemide | |
| Tramadol | Nelfinavir | |
| Venlafaxine * | Norfluoxetine | |
| Vortioxetine | Paroxetine | |
| Perphenazine | ||
| Quinidine | ||
| Ranitidine | ||
| Ritonavir | ||
| Sertraline | ||
| Terbinafine | ||
| Thioridazine | ||
| Tranylcypromine |
Phenothiazines include: Chlorpromazine, fluphenazine, perphenazine, promethazine, thioridazine; tricyclic antidepressants include: Amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine; * Metabolized to active compound; ω-3 fatty acids can inhibit CYP2D6 activity at high doses [28]; Compounds prescribed for our clinical case are indicated in bold. Table revised from literature supplied by Genomind, LLC (www.genomind.com).