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. 2015 Feb 27;16(3):4518–4559. doi: 10.3390/ijms16034518

Figure 5.

Figure 5

Many factors required for mitochondrial gene expression, i.e., for the biogenesis of tRNA belong to the super-family of helical repeats modular proteins [170]. In particular, key factors for tRNA biogenesis in mitochondria belong to the PPR family. (A) Experimental structure of human mitochondrial RNA polymerase elongation complex and (B) model of Arabidopsis mitochondrial RNase P (AtPRORP1) in complex with mitochondrial tRNACys, with PPR domains highlighted in blue. RNA molecules are shown in orange and DNA in grey. The functions of the respective PPR domains are related to the exit of newly transcribed RNA molecules [147] and to the specific recognition of tRNA precursors [138,153].