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. 2015 Mar 2;16(3):4642–4665. doi: 10.3390/ijms16034642

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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The pharmacological effects of MPEP on the CCI-induced peripheral hypersensitivities. The effects of MPEP, a selective mGluR5 antagonist, were applied on CCI by intraplantar injections to assess the (A) thermal hyperalgesia and (B) mechanical allodynia following post-injection hour (PIH). The differences in withdrawal latency and mechanical threshold were calculated by subtracting the responses of contralateral side from the responses of ipsilateral side and presented as the mean ± SD. The properties of MPEP were verified at the concentration of 500 mM (filled circles with solid line) and 250 mM (filled circles with dash line), and vehicle (open circles with dotted line) (n = 6 per group). Student’s t test was applied to examine the differences compared to vehicle injections at the same time points. One-way repeated measures ANOVA was also used to analyze the within-group differences following Dunnett’s multiple comparison tests. * p < 0.05, indicated as a significant difference.

The pharmacological effects of MPEP on the CCI-induced peripheral hypersensitivities. The effects of MPEP, a selective mGluR5 antagonist, were applied on CCI by intraplantar injections to assess the (A) thermal hyperalgesia and (B) mechanical allodynia following post-injection hour (PIH). The differences in withdrawal latency and mechanical threshold were calculated by subtracting the responses of contralateral side from the responses of ipsilateral side and presented as the mean ± SD. The properties of MPEP were verified at the concentration of 500 mM (filled circles with solid line) and 250 mM (filled circles with dash line), and vehicle (open circles with dotted line) (n = 6 per group). Student’s t test was applied to examine the differences compared to vehicle injections at the same time points. One-way repeated measures ANOVA was also used to analyze the within-group differences following Dunnett’s multiple comparison tests. * p < 0.05, indicated as a significant difference.