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UbcH10 knockdown increases the sensitivity of resistant cells to chemotherapeutics. (A) IC50s of EPB and TXT for MCF-7 and MCF-7/EPB/TXT cells. Data are expressed as mean ± SD of at least three independent experiments. * p < 0.05 and ** p < 0.01, when compared to the Con group; (B) Apoptosis caused by EPB and TXT in MCF-7 and MCF-7/EPB/TXT cells; and (C) Representative plots of MCF-7 and MCF-7/EPB/TXT cells with or without UbcH10 knockdown treated with EBP/TXT.
