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. 2015 Mar 9;16(3):5334–5346. doi: 10.3390/ijms16035334

Figure 1.

Figure 1

Molecular therapeutic strategies to restore dystrophin expression in Duchenne Muscular Dystrophy (DMD) patients. Reading frame restoration could be achieved in different combinations; (A) for an exon 45 deletion, the reading frame could be restored by targeted skipping of exons 44 or 46; while (B) and (C) show other in-frame combinations that allow the production of shorter dystrophins; (D) the IRES-induced translation mechanism; alternative initiation codon in exon 6 rescues dystrophin production (E) and (F) show the ribosomal read-through of a premature stop codon by the therapeutic agent Ataluren.