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. 2015 Mar 11;16(3):5555–5571. doi: 10.3390/ijms16035555

Figure 1.

Figure 1

Palmitoylethanolamide (PEA) inhibits 4-aminopyridine-evoked release of glutamate in rat cerebrocortical nerve terminals. (a) Glutamate release was evoked by the addition of 1 mM 4-aminopyridine in the absence (control) and in the presence of PEA (5 μM) or palmitic acid (10 μM), added 10 min prior to the addition of 4-aminopyridine; (b) Concentration-effect relationship of PEA (1–20 μM) on 4-aminopyridine-induced glutamate release. Results are mean ± SEM of 5–14 independent experiments. *** p < 0.001 versus control group.